Immunohistochemical evaluation for integrin binding sialoprotein on healing process of intrabony defect treated by bone sialoprotein

Background: Bone defect healing is a multidimensional procedure with an overlapping timeline that involves the regeneration of bone tissue. Due to bone's ability regenerate, vast majority abnormalities can be restored intuitively under right physiological conditions. The goal this study examine immunohistochemistry sialoprotein in order determine effect local application on rat tibia generated defect. Materials and Methods: In experiment, 48 albino male rats weighing 300-400 grams aged 6-8 months will employed controlled temperature, drinking, food consumption settings. animals subjected surgical medial side tibiae bone, repaired absorbable hemostatic material control group (12 rats). experimental rats) treated administration 30 μl fixed by sponge. After surgery, slaughtered at 7, 14, 28 days (four for each period). Results: Immunohistochemical analysis stromal cells reveal substantial difference between group. Conclusion: concludes could successful therapeutic treatment injuries; these findings are encouraging future clinical use.